Endocrine Abstracts

Introduction: Grave’s disease is an autoimmune disorder and is considered the most common cause of hyperthyroidism. Its treatment options include medical therapy, radioactive iodine (RAI), and surgery. RAI is commonly employed for Grave’s disease regarding its efficiency and safety. Definitive hypothyroidism is the main goal of RAI and is typically achieved within the first 3 to 6 months of therapy. Transient hypothyroidism and recurrence of hyperthyroidism after RAI...

Introduction: Pituitary insufficiency is a late-onset sequel of cranial irradiation for nasopharyngeal tumors. In a Cancer Survivor Study, 43% of patients treated for nasopharyngeal tumors had one or more endocrinopathies. We aim to characterize the pituitary-related outcomes following cranial radiotherapy for nasopharyngeal tumors over a period of 5 years.Material and methods: The effects of cranial irradiation on hypothalamic-pituitary function were st...

Introduction: Cushing’s disease (CD) is associated with metabolic and cardiovascular comorbidities that can be incompletely resolved after disease remission. Our objective was to evaluate the metabolic and cardiovascular status of patients with MC in remissionPatients and methods: We performed a retrospective study including 15 CD patients cured by pituitary surgery. Patient’s medical records were reviewed and information regarding blood pressu...

Background: Antithyroid drugs (ATD) are indicated as first intension in the treatment of Graves’disease (GD). Only two molecules are marketed in Tunisia: Benzylthiouracil (BTU) and Methimazole (MMI). There is still no clear conclusion about the choice of appropriate drug. Our objective was to compare the MMI treatment with the BTU in terms of efficacy and adverse effects (AEs).Methods: It’s a retrospective study. We studied patients with a firs...

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that result from the deficiency of one of several enzymes involved in the steroidogenic pathway for cortisol biosynthesis. The most common cause of CAH, accounting for 90% of cases, is 21-hydroxylase deficiency. The symptoms of disease very depending on the nature and severity of the enzyme deficiency as well as the sex of the individual. Non-classical CAH is generally late onset. Ho...

Introduction: Central diabetes insipidus (CDI) is a heterogeneous condition characterized by the presence of polyuria and polydipsia due to a deficiency of arginine vasopressin. Frequently, CDI is wrongly considered idiopathic if not associated with other signs and symptoms.Case report: We report the case of a 50-year-old woman diagnosed with idiopathic central diabetes insipidus at the age of 34. The MRI scan of the hypothalamus and pituitary gland was ...

Introduction: Acromegaly is a chronic disorder usually caused by growth hormone (GH)-secreting pituitary adenomas. Transsphenoidal surgery remains a treatment of choice for restoring GH to normal levels. The aim of this study was to illustrate the relationship between some factors and transsphenoidal surgery outcomes.Patients and methods: We retrospectively analysed the outcome of 31 patients with acromegaly after initial endoscopic transsphenoidal surge...

Introduction: Adrenal hemangioma (AH) is a benign vascular tumor of the adrenal gland. The adrenal site of an hemangioma is extremely rare occurring only in 0.01% of cases and accounts for 63 reported cases in the literature. AH are often discovered as incidentalomas either by imaging studies or histologic examination. The role of computed tomography (CT) scan and Magnetic resonance imaging (MRI) is important for the differential diagnosis.Case report: W...

Introduction: VonHippel Lindau (VHL) disease is an autosomal dominant disorder, responsible of the occurrence of multiple endocrine and non-endocrine lesions. When it comes to this hereditary syndrom., pheochromocytoma and pancreatic neuroendocrine tumors (pNET) require special monitoring and an appropriate treatment, The object of this case report is to highlight the different clinical presentation of the same lesion in the same patient and the difficulties in decisions&#8217...

Introduction: Primary and nonsuppressible hypersecretion of aldosterone is an increasingly recognized, but still underdiagnosed, cause of hypertension. Our objective is to determine the evolution features of primary aldosteronism (PA) patients.Patients and Methods: Retrospective study of 17 patients with PA confirmed biochemically and histologically when operated.Results: The mean age was 41.9 ± 9.3 years at PA diagnosis, and ...